1cdm: Difference between revisions

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[[Image:1cdm.gif|left|200px]]<br /><applet load="1cdm" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1cdm.gif|left|200px]]<br /><applet load="1cdm" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1cdm, resolution 2.0Å" />

'''MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES'''<br />

==Overview==

Calmodulin is the primary calcium-dependent signal transducer and, regulator of a wide variety of essential cellular functions. The structure, of calcium-calmodulin bound to the peptide corresponding to the, calmodulin-binding domain of brain calmodulin-dependent protein kinase II, alpha was determined to 2 angstrom resolution. A comparison to two other, calcium-calmodulin structures reveals how the central helix unwinds in, order to position the two domains optimally in the recognition of, different target enzymes and clarifies the role of calcium in maintaining, recognition-competent domain structures.

Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

==About this Structure==

1CDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1CDM OCA].

1CDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDM OCA].

==Reference==

Line 13:

[[Category: Bos taurus]]

[[Category: Protein complex]]

[[Category: Meador, W.E.]]

[[Category: Meador, W E.]]

[[Category: Quiocho, F.A.]]

[[Category: Quiocho, F A.]]

[[Category: CA]]

[[Category: calcium-binding protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 12:22:~~11 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:05:01 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1cdm.gif|left|200px]]<br /><applet load="1cdm" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1cdm.gif|left|200px]]<br /><applet load="1cdm" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1cdm, resolution 2.0&Aring;" />
 '''MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES'''<br />
 ==Overview==
-Calmodulin is the primary calcium-dependent signal transducer and, regulator of a wide variety of essential cellular functions. The structure, of calcium-calmodulin bound to the peptide corresponding to the, calmodulin-binding domain of brain calmodulin-dependent protein kinase II, alpha was determined to 2 angstrom resolution. A comparison to two other, calcium-calmodulin structures reveals how the central helix unwinds in, order to position the two domains optimally in the recognition of, different target enzymes and clarifies the role of calcium in maintaining, recognition-competent domain structures.
+Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.
 ==About this Structure==
-CDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CDM OCA].
+CDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDM OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bos taurus]]
 [[Category: Protein complex]]
-[[Category: Meador, W.E.]]
+[[Category: Meador, W E.]]
-[[Category: Quiocho, F.A.]]
+[[Category: Quiocho, F A.]]
 [[Category: CA]]
 [[Category: calcium-binding protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:22:11 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:05:01 2008''