3kc3: Difference between revisions

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{{Seed}}
[[Image:3kc3.png|left|200px]]
[[Image:3kc3.png|left|200px]]


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{{STRUCTURE_3kc3|  PDB=3kc3  |  SCENE=  }}  
{{STRUCTURE_3kc3|  PDB=3kc3  |  SCENE=  }}  


===MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine===
===MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine===


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{{ABSTRACT_PUBMED_19919896}}
{{ABSTRACT_PUBMED_19919896}}


==About this Structure==
==About this Structure==
3KC3 is a 12 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KC3 OCA].  
[[3kc3]] is a 12 chain structure of [[Mitogen-activated protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KC3 OCA].  
 
==See Also==
*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:19919896</ref><references group="xtra"/>
<ref group="xtra">PMID:019919896</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
Line 29: Line 20:
[[Category: Borhani, D W.]]
[[Category: Borhani, D W.]]
[[Category: Talanian, R V.]]
[[Category: Talanian, R V.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Diaminopyrimidine]]
[[Category: Diaminopyrimidine]]
Line 37: Line 27:
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Tnfalpha]]
[[Category: Tnfalpha]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:34:15 2010''

Revision as of 00:30, 26 July 2012

File:3kc3.png

Template:STRUCTURE 3kc3

MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine

Template:ABSTRACT PUBMED 19919896

About this Structure

3kc3 is a 12 chain structure of Mitogen-activated protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Argiriadi MA, Ericsson AM, Harris CM, Banach DL, Borhani DW, Calderwood DJ, Demers MD, Dimauro J, Dixon RW, Hardman J, Kwak S, Li B, Mankovich JA, Marcotte D, Mullen KD, Ni B, Pietras M, Sadhukhan R, Sousa S, Tomlinson MJ, Wang L, Xiang T, Talanian RV. 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Bioorg Med Chem Lett. 2010 Jan 1;20(1):330-3. Epub 2009 Oct 29. PMID:19919896 doi:10.1016/j.bmcl.2009.10.102

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