1cmb: Difference between revisions
New page: left|200px<br /><applet load="1cmb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cmb, resolution 1.8Å" /> '''THREE DIMENSIONAL CRY... |
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[[Image:1cmb.gif|left|200px]]<br /><applet load="1cmb" size=" | [[Image:1cmb.gif|left|200px]]<br /><applet load="1cmb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1cmb, resolution 1.8Å" /> | caption="1cmb, resolution 1.8Å" /> | ||
'''THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''<br /> | '''THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''<br /> | ||
==Overview== | ==Overview== | ||
The three-dimensional crystal structure of met repressor, in the presence | The three-dimensional crystal structure of met repressor, in the presence or absence of bound corepressor (S-adenosylmethionine), shows a dimer of intertwined monomers, which do not have the helix-turn-helix motif characteristic of other bacterial repressor and activator structures. We propose that the interaction of met repressor with DNA occurs through either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions. | ||
==About this Structure== | ==About this Structure== | ||
1CMB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1CMB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Phillips, K.]] | [[Category: Phillips, K.]] | ||
[[Category: Phillips, S | [[Category: Phillips, S E.V.]] | ||
[[Category: Rafferty, J | [[Category: Rafferty, J B.]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: dna-binding regulatory protein]] | [[Category: dna-binding regulatory protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:29 2008'' | ||
Revision as of 10:07, 21 February 2008
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THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR
Overview
The three-dimensional crystal structure of met repressor, in the presence or absence of bound corepressor (S-adenosylmethionine), shows a dimer of intertwined monomers, which do not have the helix-turn-helix motif characteristic of other bacterial repressor and activator structures. We propose that the interaction of met repressor with DNA occurs through either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.
About this Structure
1CMB is a Single protein structure of sequence from Escherichia coli with PO4 as ligand. Full crystallographic information is available from OCA.
Reference
Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor., Rafferty JB, Somers WS, Saint-Girons I, Phillips SE, Nature. 1989 Oct 26;341(6244):705-10. PMID:2677753
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