1cnp: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The S100 calcium-binding proteins are implicated as effectors in | The S100 calcium-binding proteins are implicated as effectors in calcium-mediated signal transduction pathways. The three-dimensional structure of the S100 protein calcyclin has been determined in solution in the apo state by NMR spectroscopy and a computational strategy that incorporates a systematic docking protocol. This structure reveals a symmetric homodimeric fold that is unique among calcium-binding proteins. Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins. | ||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 14: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Akke, M.]] | [[Category: Akke, M.]] | ||
[[Category: Case, D | [[Category: Case, D A.]] | ||
[[Category: Chazin, W | [[Category: Chazin, W J.]] | ||
[[Category: Hidaka, H.]] | [[Category: Hidaka, H.]] | ||
[[Category: Macke, T | [[Category: Macke, T J.]] | ||
[[Category: Okazaki, K.]] | [[Category: Okazaki, K.]] | ||
[[Category: Potts, B | [[Category: Potts, B C.M.]] | ||
[[Category: Smith, J.]] | [[Category: Smith, J.]] | ||
[[Category: calcium-binding protein]] | [[Category: calcium-binding protein]] | ||
| Line 25: | Line 25: | ||
[[Category: s-100 protein]] | [[Category: s-100 protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:58 2008'' | ||
