1cos: Difference between revisions

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==Overview==

The x-ray crystal structure of a peptide designed to form a, double-stranded parallel coiled coil shows that it is actually a, triple-stranded coiled coil formed by three alpha-helices. Unlike the, designed parallel coiled coil, the helices run up-up-down. The structure, is stabilized by a distinctive hydrophobic interface consisting of eight, layers. As in the design, each alpha-helix in the coiled coil contributes, one leucine side chain to each layer. The structure suggests that, hydrophobic interactions are a dominant factor in the stabilization of, coiled coils. The stoichiometry and geometry of coiled coils are primarily, determined by side chain packing in the solvent-inaccessible interior, but, electrostatic interactions also contribute.

The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.

==About this Structure==

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[[Category: Eisenberg, D.]]

[[Category: Lovejoy, B.]]

[[Category: Mcrorie, D.K.]]

[[Category: Mcrorie, D K.]]

[[Category: ACE]]

[[Category: NH2]]

[[Category: alpha-helical bundle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 15~~:36:28 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:08:11 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The x-ray crystal structure of a peptide designed to form a, double-stranded parallel coiled coil shows that it is actually a, triple-stranded coiled coil formed by three alpha-helices. Unlike the, designed parallel coiled coil, the helices run up-up-down. The structure, is stabilized by a distinctive hydrophobic interface consisting of eight, layers. As in the design, each alpha-helix in the coiled coil contributes, one leucine side chain to each layer. The structure suggests that, hydrophobic interactions are a dominant factor in the stabilization of, coiled coils. The stoichiometry and geometry of coiled coils are primarily, determined by side chain packing in the solvent-inaccessible interior, but, electrostatic interactions also contribute.
+The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.
 ==About this Structure==
@@ Line 18: / Line 18: @@
 [[Category: Eisenberg, D.]]
 [[Category: Lovejoy, B.]]
-[[Category: Mcrorie, D.K.]]
+[[Category: Mcrorie, D K.]]
 [[Category: ACE]]
 [[Category: NH2]]
 [[Category: alpha-helical bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:36:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:08:11 2008''