2h9h: Difference between revisions

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[[Image:2h9h.png|left|200px]]
[[Image:2h9h.png|left|200px]]


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{{STRUCTURE_2h9h|  PDB=2h9h  |  SCENE=  }}  
{{STRUCTURE_2h9h|  PDB=2h9h  |  SCENE=  }}  


===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors===
===An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors===


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{{ABSTRACT_PUBMED_16860823}}
{{ABSTRACT_PUBMED_16860823}}


==About this Structure==
==About this Structure==
[[2h9h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9H OCA].  
[[2h9h]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9H OCA].  
 
==See Also==
*[[Virus protease|Virus protease]]


==Reference==
==Reference==
<ref group="xtra">PMID:16860823</ref><ref group="xtra">PMID:16288920</ref><references group="xtra"/>
<ref group="xtra">PMID:016860823</ref><ref group="xtra">PMID:016288920</ref><references group="xtra"/>
[[Category: Hepatitis a virus]]
[[Category: Hepatitis a virus]]
[[Category: Picornain 3C]]
[[Category: Picornain 3C]]
Line 29: Line 21:
[[Category: James, M N.]]
[[Category: James, M N.]]
[[Category: Yin, J.]]
[[Category: Yin, J.]]
[[Category: 3c protease]]
[[Category: Catalytic triad]]
[[Category: Episulfide]]
[[Category: Episulfide]]
[[Category: Hepatitis a virus]]
[[Category: Hydrolase-hydrlase inhibitor complex]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor design]]
[[Category: Methylketone]]
[[Category: Methylketone]]
[[Category: Picornain]]

Revision as of 03:09, 26 July 2012

File:2h9h.png

Template:STRUCTURE 2h9h

An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors

Template:ABSTRACT PUBMED 16860823

About this Structure

2h9h is a 2 chain structure of Virus protease with sequence from Hepatitis a virus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN. An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:16860823 doi:10.1016/j.jmb.2006.06.047
  2. Yin J, Bergmann EM, Cherney MM, Lall MS, Jain RP, Vederas JC, James MN. Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site. J Mol Biol. 2005 Dec 9;354(4):854-71. Epub 2005 Oct 14. PMID:16288920 doi:10.1016/j.jmb.2005.09.074

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