1ctr: Difference between revisions

Line 4:

==Overview==

The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP), has been determined and refined to a resolution of 2.45 A. Only one TFP is, bound to CaM, but that is sufficient to cause distortion of the central, alpha-helix and juxtaposition of the N- and C-terminal domains similar to, that seen in CaM-polypeptide complexes. The drug makes extensive contacts, with residues in the C-terminal domain of CaM but only a few contacts with, one residue in the N-terminal domain. The structure suggests that, substrate binding to the C-terminal domain is sufficient to cause the, conformational changes in calmodulin that lead to activation of its, targets.

The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP) has been determined and refined to a resolution of 2.45 A. Only one TFP is bound to CaM, but that is sufficient to cause distortion of the central alpha-helix and juxtaposition of the N- and C-terminal domains similar to that seen in CaM-polypeptide complexes. The drug makes extensive contacts with residues in the C-terminal domain of CaM but only a few contacts with one residue in the N-terminal domain. The structure suggests that substrate binding to the C-terminal domain is sufficient to cause the conformational changes in calmodulin that lead to activation of its targets.

==Disease==

Line 16:

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Cook, W.J.]]

[[Category: Cook, W J.]]

[[Category: Walter, L.J.]]

[[Category: Walter, L J.]]

[[Category: Walter, M.R.]]

[[Category: Walter, M R.]]

[[Category: CA]]

[[Category: TFP]]

[[Category: calcium-binding protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 15~~:37:12 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:36 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP), has been determined and refined to a resolution of 2.45 A. Only one TFP is, bound to CaM, but that is sufficient to cause distortion of the central, alpha-helix and juxtaposition of the N- and C-terminal domains similar to, that seen in CaM-polypeptide complexes. The drug makes extensive contacts, with residues in the C-terminal domain of CaM but only a few contacts with, one residue in the N-terminal domain. The structure suggests that, substrate binding to the C-terminal domain is sufficient to cause the, conformational changes in calmodulin that lead to activation of its, targets.
+The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP) has been determined and refined to a resolution of 2.45 A. Only one TFP is bound to CaM, but that is sufficient to cause distortion of the central alpha-helix and juxtaposition of the N- and C-terminal domains similar to that seen in CaM-polypeptide complexes. The drug makes extensive contacts with residues in the C-terminal domain of CaM but only a few contacts with one residue in the N-terminal domain. The structure suggests that substrate binding to the C-terminal domain is sufficient to cause the conformational changes in calmodulin that lead to activation of its targets.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Cook, W.J.]]
+[[Category: Cook, W J.]]
-[[Category: Walter, L.J.]]
+[[Category: Walter, L J.]]
-[[Category: Walter, M.R.]]
+[[Category: Walter, M R.]]
 [[Category: CA]]
 [[Category: TFP]]
 [[Category: calcium-binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:37:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:09:36 2008''