3m37: Difference between revisions
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Revision as of 04:21, 26 July 2012
Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)
Template:ABSTRACT PUBMED 14640539
About this Structure
3m37 is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539 doi:10.1021/jm030212h
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Coagulation factor Xa
- Homo sapiens
- Alexander, R S.
- Blood coagulation
- Blood coagulation factor
- Calcium- binding
- Cleavage on pair of basic residue
- Disulfide bond
- Egf-like domain
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Plasma
- Protease
- Protein inhibitor complex
- Secreted
- Serine protease
- Zymogen
