2pl0: Difference between revisions

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{{Seed}}
[[Image:2pl0.png|left|200px]]
[[Image:2pl0.png|left|200px]]


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{{STRUCTURE_2pl0|  PDB=2pl0  |  SCENE=  }}  
{{STRUCTURE_2pl0|  PDB=2pl0  |  SCENE=  }}  


===LCK bound to imatinib===
===LCK bound to imatinib===


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{{ABSTRACT_PUBMED_17910071}}
{{ABSTRACT_PUBMED_17910071}}


==Disease==
==About this Structure==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
[[2pl0]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL0 OCA].


==About this Structure==
==See Also==
2PL0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PL0 OCA].
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
*[[Tyrosine kinase|Tyrosine kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:17910071</ref><references group="xtra"/>
<ref group="xtra">PMID:017910071</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Kinase phosphorylation]]
[[Category: Kinase phosphorylation]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:23:36 2009''

Revision as of 04:40, 26 July 2012

File:2pl0.png

Template:STRUCTURE 2pl0

LCK bound to imatinib

Template:ABSTRACT PUBMED 17910071

About this Structure

2pl0 is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Jacobs MD, Caron PR, Hare BJ. Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex. Proteins. 2007 Oct 1;70(4):1451-1460. PMID:17910071 doi:10.1002/prot.21633

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