1d5s: Difference between revisions

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[[Image:1d5s.gif|left|200px]]<br />

[[Image:1d5s.gif|left|200px]]<br /><applet load="1d5s" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1d5s" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1d5s, resolution 3.0Å" />

'''CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER'''<br />

==Overview==

Alpha1-antitrypsin deficiency, which can lead to both emphysema and liver, disease, is a result of the accumulation of alpha1-antitrypsin polymers, within the hepatocyte. A wealth of biochemical and biophysical data, suggests that alpha1-antitrypsin polymers form via insertion of residues, from the reactive center loop of one molecule into the beta-sheet of, another. However, this long-standing hypothesis has not been confirmed by, direct structural evidence. Here, we describe the first crystallographic, evidence of a beta-strand linked polymer form of alpha1-antitrypsin: the, crystal structure of a cleaved alpha1-antitrypsin polymer.

Alpha1-antitrypsin deficiency, which can lead to both emphysema and liver disease, is a result of the accumulation of alpha1-antitrypsin polymers within the hepatocyte. A wealth of biochemical and biophysical data suggests that alpha1-antitrypsin polymers form via insertion of residues from the reactive center loop of one molecule into the beta-sheet of another. However, this long-standing hypothesis has not been confirmed by direct structural evidence. Here, we describe the first crystallographic evidence of a beta-strand linked polymer form of alpha1-antitrypsin: the crystal structure of a cleaved alpha1-antitrypsin polymer.

==Disease==

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==About this Structure==

1D5S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1D5S OCA].

1D5S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5S OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Bonneic, B.F.Le.]]

[[Category: Bonneic, B F.Le.]]

[[Category: Bottomley, S.P.]]

[[Category: Bottomley, S P.]]

[[Category: Dai, W.]]

[[Category: Dunstone, M.A.]]

[[Category: Dunstone, M A.]]

[[Category: Feil, S.C.]]

[[Category: Feil, S C.]]

[[Category: Parker, M.W.]]

[[Category: Parker, M W.]]

[[Category: Pike, R.N.]]

[[Category: Pike, R N.]]

[[Category: Rossjohn, J.]]

[[Category: Whisstock, J.C.]]

[[Category: Whisstock, J C.]]

[[Category: a beta sheet polymerisation]]

[[Category: rcl cleavage]]

[[Category: serpin fold]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:29:~~24 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:13:17 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1d5s.gif|left|200px]]<br />
+[[Image:1d5s.gif|left|200px]]<br /><applet load="1d5s" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1d5s" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1d5s, resolution 3.0&Aring;" />
 '''CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER'''<br />
 ==Overview==
-Alpha1-antitrypsin deficiency, which can lead to both emphysema and liver, disease, is a result of the accumulation of alpha1-antitrypsin polymers, within the hepatocyte. A wealth of biochemical and biophysical data, suggests that alpha1-antitrypsin polymers form via insertion of residues, from the reactive center loop of one molecule into the beta-sheet of, another. However, this long-standing hypothesis has not been confirmed by, direct structural evidence. Here, we describe the first crystallographic, evidence of a beta-strand linked polymer form of alpha1-antitrypsin: the, crystal structure of a cleaved alpha1-antitrypsin polymer.
+Alpha1-antitrypsin deficiency, which can lead to both emphysema and liver disease, is a result of the accumulation of alpha1-antitrypsin polymers within the hepatocyte. A wealth of biochemical and biophysical data suggests that alpha1-antitrypsin polymers form via insertion of residues from the reactive center loop of one molecule into the beta-sheet of another. However, this long-standing hypothesis has not been confirmed by direct structural evidence. Here, we describe the first crystallographic evidence of a beta-strand linked polymer form of alpha1-antitrypsin: the crystal structure of a cleaved alpha1-antitrypsin polymer.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-D5S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D5S OCA].
+D5S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5S OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Bonneic, B.F.Le.]]
+[[Category: Bonneic, B F.Le.]]
-[[Category: Bottomley, S.P.]]
+[[Category: Bottomley, S P.]]
 [[Category: Dai, W.]]
-[[Category: Dunstone, M.A.]]
+[[Category: Dunstone, M A.]]
-[[Category: Feil, S.C.]]
+[[Category: Feil, S C.]]
-[[Category: Parker, M.W.]]
+[[Category: Parker, M W.]]
-[[Category: Pike, R.N.]]
+[[Category: Pike, R N.]]
 [[Category: Rossjohn, J.]]
-[[Category: Whisstock, J.C.]]
+[[Category: Whisstock, J C.]]
 [[Category: a beta sheet polymerisation]]
 [[Category: rcl cleavage]]
 [[Category: serpin fold]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:29:24 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:13:17 2008''