3cde: Difference between revisions

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{{Seed}}
[[Image:3cde.png|left|200px]]
[[Image:3cde.jpg|left|200px]]


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{{STRUCTURE_3cde|  PDB=3cde  |  SCENE=  }}  
{{STRUCTURE_3cde|  PDB=3cde  |  SCENE=  }}  


===Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor===
===Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor===


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{{ABSTRACT_PUBMED_18457949}}
{{ABSTRACT_PUBMED_18457949}}


==About this Structure==
==About this Structure==
3CDE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDE OCA].  
[[3cde]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDE OCA].  
 
==See Also==
*[[RNA polymerase|RNA polymerase]]


==Reference==
==Reference==
<ref group="xtra">PMID:18457949</ref><references group="xtra"/>
<ref group="xtra">PMID:018457949</ref><references group="xtra"/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: Viral nucleoprotein]]
[[Category: Viral nucleoprotein]]
[[Category: Virion]]
[[Category: Virion]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  4 14:41:36 2009''

Revision as of 06:31, 26 July 2012

File:3cde.png

Template:STRUCTURE 3cde

Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor

Template:ABSTRACT PUBMED 18457949

About this Structure

3cde is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072

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