1dc0: Difference between revisions

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[[Image:1dc0.gif|left|200px]]<br /><applet load="1dc0" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1dc0.gif|left|200px]]<br /><applet load="1dc0" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1dc0, resolution 1.3Å" />

'''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG'''<br />

==Overview==

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A, has a conformation intermediate between A and B DNA. This trapping of a, stable intermediate suggests that the A and B DNA families are not, discrete, as previously believed. The structure supports a base-centered, rather than a backbone-centered mechanism for the A <--> B transition, mediated by guanine tracts. Interconversion between A and B DNA provides, another means for regulating protein-DNA recognition.

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

==About this Structure==

1DC0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA].

1DC0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA].

==Reference==

The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10688897 10688897]

[[Category: Protein complex]]

[[Category: Dickerson, R.E.]]

[[Category: Dickerson, R E.]]

[[Category: Kopka, M.L.]]

[[Category: Kopka, M L.]]

[[Category: Ng, H. L.]]

[[Category: a-dna]]

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[[Category: intermediate]]

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@@ Line 1: / Line 1: @@
-[[Image:1dc0.gif|left|200px]]<br /><applet load="1dc0" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dc0.gif|left|200px]]<br /><applet load="1dc0" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1dc0, resolution 1.3&Aring;" />
 '''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG'''<br />
 ==Overview==
-The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A, has a conformation intermediate between A and B DNA. This trapping of a, stable intermediate suggests that the A and B DNA families are not, discrete, as previously believed. The structure supports a base-centered, rather than a backbone-centered mechanism for the A &lt;--&gt; B transition, mediated by guanine tracts. Interconversion between A and B DNA provides, another means for regulating protein-DNA recognition.
+The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A &lt;--&gt; B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.
 ==About this Structure==
-DC0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA].
+DC0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA].
 ==Reference==
 The structure of a stable intermediate in the A &lt;--&gt; B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10688897 10688897]
 [[Category: Protein complex]]
-[[Category: Dickerson, R.E.]]
+[[Category: Dickerson, R E.]]
-[[Category: Kopka, M.L.]]
+[[Category: Kopka, M L.]]
 [[Category: Ng, H. L.]]
 [[Category: a-dna]]
@@ Line 19: / Line 19: @@
 [[Category: intermediate]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:56:38 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:03 2008''