1fss: Difference between revisions

Revision as of 08:34, 26 July 2012

Ligands:

NAG, ZN

Activity:

Acetylcholinesterase, with EC number 3.1.1.7

Structural annotation:
Resources:	CATH : 1Fssa00, 1Fssb00 InterPro : Ipr000997, Ipr002018, Ipr000908 Pfam : PF00135 SCOP : d1fssa_, d1fssb_ UniProt : P04058, P0C1Z0

Functional annotation:
Cellular component:	cell junction membrane synapse
Biological process:	neurotransmitter catabolic process acetylcholine catabolic process in synaptic cleft
Molecular function:	GPI anchor binding cholinesterase activity acetylcholinesterase activity hydrolase activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1fss is a 2 chain structure of Acetylcholinesterase and Fasciculin with sequence from Dendroaspis angusticeps and Torpedo californica. Full crystallographic information is available from OCA.

Harel M, Kleywegt GJ, Ravelli RB, Silman I, Sussman JL. Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. Structure. 1995 Dec 15;3(12):1355-66. PMID:8747462

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 [[Image:1fss.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1fss", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_1fss|  PDB=1fss  |  SCENE=  }}
 ===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II===
-<!--
-The line below this paragraph, {{ABSTRACT_PUBMED_8747462}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 8747462 is the PubMed ID number.
--->
 {{ABSTRACT_PUBMED_8747462}}
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 *[[AChE inhibitors and substrates|AChE inhibitors and substrates]]
 *[[Acetylcholinesterase|Acetylcholinesterase]]
-*[[Acetylcholinesterase: Substrate Traffic and Inhibition|Acetylcholinesterase: Substrate Traffic and Inhibition]]
 *[[Fasciculin|Fasciculin]]
-*[[Group:SMART:Acetylcholinesterase:A Story of Substrate Traffic and Inhibition by Green Mamba Snake Toxin|SMART:Acetylcholinesterase:A Story of Substrate Traffic and Inhibition by Green Mamba Snake Toxin]]
-*[[Structure Gallery Generator|Structure Gallery Generator]]
 ==Reference==