1eby: Difference between revisions

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[[Image:1eby.png|left|200px]]
[[Image:1eby.png|left|200px]]


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{{STRUCTURE_1eby|  PDB=1eby  |  SCENE=  }}  
{{STRUCTURE_1eby|  PDB=1eby  |  SCENE=  }}  


===HIV-1 protease in complex with the inhibitor BEA369===
===HIV-1 protease in complex with the inhibitor BEA369===


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{{ABSTRACT_PUBMED_12694187}}
{{ABSTRACT_PUBMED_12694187}}


==About this Structure==
==About this Structure==
[[1eby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EBY OCA].  
[[1eby]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EBY OCA].  
 
==See Also==
*[[Virus protease|Virus protease]]


==Reference==
==Reference==
<ref group="xtra">PMID:12694187</ref><ref group="xtra">PMID:15560801</ref><references group="xtra"/>
<ref group="xtra">PMID:012694187</ref><ref group="xtra">PMID:015560801</ref><references group="xtra"/>
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Unge, T.]]
[[Category: Unge, T.]]
[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Hydrolase/hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]

Revision as of 09:48, 26 July 2012

File:1eby.png

Template:STRUCTURE 1eby

HIV-1 protease in complex with the inhibitor BEA369

Template:ABSTRACT PUBMED 12694187

About this Structure

1eby is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

See Also

Reference

  1. Andersson HO, Fridborg K, Lowgren S, Alterman M, Muhlman A, Bjorsne M, Garg N, Kvarnstrom I, Schaal W, Classon B, Karlen A, Danielsson UH, Ahlsen G, Nillroth U, Vrang L, Oberg B, Samuelsson B, Hallberg A, Unge T. Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors. Eur J Biochem. 2003 Apr;270(8):1746-58. PMID:12694187
  2. Lindberg J, Pyring D, Lowgren S, Rosenquist A, Zuccarello G, Kvarnstrom I, Zhang H, Vrang L, Classon B, Hallberg A, Samuelsson B, Unge T. Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy. Eur J Biochem. 2004 Nov;271(22):4594-602. PMID:15560801 doi:10.1111/j.1432-1033.2004.04431.x

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