1dul: Difference between revisions
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New page: left|200px<br /><applet load="1dul" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dul, resolution 1.80Å" /> '''STRUCTURE OF THE RIB... |
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[[Image:1dul.jpg|left|200px]]<br /><applet load="1dul" size=" | [[Image:1dul.jpg|left|200px]]<br /><applet load="1dul" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1dul, resolution 1.80Å" /> | caption="1dul, resolution 1.80Å" /> | ||
'''STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE'''<br /> | '''STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE'''<br /> | ||
==Overview== | ==Overview== | ||
The signal recognition particle (SRP), a protein-RNA complex conserved in | The signal recognition particle (SRP), a protein-RNA complex conserved in all three kingdoms of life, recognizes and transports specific proteins to cellular membranes for insertion or secretion. We describe here the 1.8 angstrom crystal structure of the universal core of the SRP, revealing protein recognition of a distorted RNA minor groove. Nucleotide analog interference mapping demonstrates the biological importance of observed interactions, and genetic results show that this core is functional in vivo. The structure explains why the conserved residues in the protein and RNA are required for SRP assembly and defines a signal sequence recognition surface composed of both protein and RNA. | ||
==About this Structure== | ==About this Structure== | ||
1DUL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with K and MG as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1DUL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUL OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Batey, R | [[Category: Batey, R T.]] | ||
[[Category: Doudna, J.]] | [[Category: Doudna, J.]] | ||
[[Category: Lucast, L.]] | [[Category: Lucast, L.]] | ||
[[Category: Rambo, R | [[Category: Rambo, R P.]] | ||
[[Category: Rha, B.]] | [[Category: Rha, B.]] | ||
[[Category: K]] | [[Category: K]] | ||
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[[Category: tetraloop]] | [[Category: tetraloop]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:20:40 2008'' | ||
