3srv: Difference between revisions

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[[Image:3srv.png|left|200px]]
[[Image:3srv.png|left|200px]]


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{{STRUCTURE_3srv|  PDB=3srv  |  SCENE=  }}  
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===Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor===
===Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor===


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{{ABSTRACT_PUBMED_21903390}}
{{ABSTRACT_PUBMED_21903390}}


==About this Structure==
==About this Structure==
[[3srv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRV OCA].  
[[3srv]] is a 2 chain structure of [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRV OCA].  
 
==See Also==
*[[Tyrosine kinase|Tyrosine kinase]]


==Reference==
==Reference==

Revision as of 11:26, 26 July 2012

File:3srv.png

Template:STRUCTURE 3srv

Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor

Template:ABSTRACT PUBMED 21903390

About this Structure

3srv is a 2 chain structure of Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Liddle J, Atkinson FL, Barker MD, Carter PS, Curtis NR, Davis RP, Douault C, Dickson MC, Elwes D, Garton NS, Gray M, Hayhow TG, Hobbs CI, Jones E, Leach S, Leavens K, Lewis HD, McCleary S, Neu M, Patel VK, Preston AG, Ramirez-Molina C, Shipley TJ, Skone PA, Smithers N, Somers DO, Walker AL, Watson RJ, Weingarten GG. Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2011 Aug 12. PMID:21903390 doi:10.1016/j.bmcl.2011.07.082

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