1pyn: Difference between revisions
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[[Image:1pyn.png|left|200px]] | [[Image:1pyn.png|left|200px]] | ||
{{STRUCTURE_1pyn| PDB=1pyn | SCENE= }} | {{STRUCTURE_1pyn| PDB=1pyn | SCENE= }} | ||
===DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE=== | ===DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE=== | ||
{{ABSTRACT_PUBMED_12951078}} | {{ABSTRACT_PUBMED_12951078}} | ||
==About this Structure== | ==About this Structure== | ||
[[1pyn]] is a 1 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PYN OCA]. | |||
==See Also== | |||
*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]] | |||
*[[Tyrosine phosphatase|Tyrosine phosphatase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:012951078</ref><ref group="xtra">PMID:015258570</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
| Line 36: | Line 28: | ||
[[Category: Trevillyan, J M.]] | [[Category: Trevillyan, J M.]] | ||
[[Category: Zhonghua, P.]] | [[Category: Zhonghua, P.]] | ||
[[Category: Hydrolase]] | |||
[[Category: Malonate-containing inhibitor]] | [[Category: Malonate-containing inhibitor]] | ||
[[Category: Protein tyrosine phosphatase inhibited with dual site]] | [[Category: Protein tyrosine phosphatase inhibited with dual site]] | ||
Revision as of 12:20, 26 July 2012
DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE
Template:ABSTRACT PUBMED 12951078
About this Structure
1pyn is a 1 chain structure of Proten tyrosine phosphatase and Tyrosine phosphatase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Pei Z, Li X, Liu G, Abad-Zapatero C, Lubben T, Zhang T, Ballaron SJ, Hutchins CW, Trevillyan JM, Jirousek MR. Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3129-32. PMID:12951078
- Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK. Allosteric inhibition of protein tyrosine phosphatase 1B. Nat Struct Mol Biol. 2004 Aug;11(8):730-7. Epub 2004 Jul 18. PMID:15258570 doi:10.1038/nsmb803
