2ph8: Difference between revisions

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Revision as of 13:08, 26 July 2012

File:2ph8.png

Template:STRUCTURE 2ph8

Crystal Structure of Human Beta Secretase Complexed with inhibitor

Template:ABSTRACT PUBMED 17827011

About this Structure

2ph8 is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Moore KP, Zhu H, Rajapakse HA, McGaughey GB, Colussi D, Price EA, Sankaranarayanan S, Simon AJ, Pudvah NT, Hochman JH, Allison T, Munshi SK, Graham SL, Vacca JP, Nantermet PG. Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5831-5. Epub 2007 Aug 23. PMID:17827011 doi:10.1016/j.bmcl.2007.08.040

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