2fm2: Difference between revisions

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{{Seed}}
[[Image:2fm2.png|left|200px]]
[[Image:2fm2.png|left|200px]]


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{{STRUCTURE_2fm2|  PDB=2fm2  |  SCENE=  }}  
{{STRUCTURE_2fm2|  PDB=2fm2  |  SCENE=  }}  


===HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211===
===HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211===


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{{ABSTRACT_PUBMED_16352601}}
{{ABSTRACT_PUBMED_16352601}}


==About this Structure==
==About this Structure==
2FM2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA].  
[[2fm2]] is a 4 chain structure of [[Helicase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM2 OCA].  
 
==See Also==
*[[Helicase|Helicase]]


==Reference==
==Reference==
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations., Yi M, Tong X, Skelton A, Chase R, Chen T, Prongay A, Bogen SL, Saksena AK, Njoroge FG, Veselenak RL, Pyles RB, Bourne N, Malcolm BA, Lemon SM, J Biol Chem. 2006 Mar 24;281(12):8205-15. Epub 2005 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16352601 16352601]
<ref group="xtra">PMID:016352601</ref><references group="xtra"/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Single protein]]
[[Category: Bogen, S L.]]
[[Category: Bogen, S L.]]
[[Category: Bourne, N.]]
[[Category: Bourne, N.]]
Line 42: Line 32:
[[Category: Hcv]]
[[Category: Hcv]]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Hydrolase]]
[[Category: Ketoamide inhibitor]]
[[Category: Ketoamide inhibitor]]
[[Category: Ns3/4a protease]]
[[Category: Ns3/4a protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:19:45 2008''

Revision as of 14:11, 26 July 2012

File:2fm2.png

Template:STRUCTURE 2fm2

HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211

Template:ABSTRACT PUBMED 16352601

About this Structure

2fm2 is a 4 chain structure of Helicase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Yi M, Tong X, Skelton A, Chase R, Chen T, Prongay A, Bogen SL, Saksena AK, Njoroge FG, Veselenak RL, Pyles RB, Bourne N, Malcolm BA, Lemon SM. Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations. J Biol Chem. 2006 Mar 24;281(12):8205-15. Epub 2005 Dec 13. PMID:16352601 doi:10.1074/jbc.M510246200

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