3emg: Difference between revisions
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[[Image:3emg.png|left|200px]] | [[Image:3emg.png|left|200px]] | ||
{{STRUCTURE_3emg| PDB=3emg | SCENE= }} | {{STRUCTURE_3emg| PDB=3emg | SCENE= }} | ||
===Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)=== | ===Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)=== | ||
{{ABSTRACT_PUBMED_18938080}} | {{ABSTRACT_PUBMED_18938080}} | ||
==About this Structure== | ==About this Structure== | ||
[[3emg]] is a 1 chain structure of [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMG OCA]. | |||
==See Also== | |||
*[[Tyrosine kinase|Tyrosine kinase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018938080</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Haar, E Ter.]] | [[Category: Haar, E Ter.]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Host-virus interaction]] | [[Category: Host-virus interaction]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Sh2 domain]] | [[Category: Sh2 domain]] | ||
[[Category: Syk]] | [[Category: Syk]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
Revision as of 14:14, 26 July 2012
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Template:ABSTRACT PUBMED 18938080
About this Structure
3emg is a 1 chain structure of Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Farmer LJ, Bemis G, Britt SD, Cochran J, Connors M, Harrington EM, Hoock T, Markland W, Nanthakumar S, Taslimi P, Ter Haar E, Wang J, Zhaveri D, Salituro FG. Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorg Med Chem Lett. 2008 Dec 1;18(23):6231-5. Epub 2008 Oct 7. PMID:18938080 doi:S0960-894X(08)01172-4
