1edn: Difference between revisions

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[[Image:1edn.gif|left|200px]]<br />

[[Image:1edn.gif|left|200px]]<br /><applet load="1edn" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1edn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1edn, resolution 2.18Å" />

'''HUMAN ENDOTHELIN-1'''<br />

==Overview==

The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by, X-ray crystallography to 2.18 A resolution. This intermediate-sized, structure was solved by molecular replacement techniques using a fragment, of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models, derived from NMR data indicate some important differences, especially in, the carboxy-terminal region of the molecule: the entire carboxy terminal, tail (residues 16-21) is helical in the crystal structure, but not in any, of the NMR structures. This may be a functionally significant difference, as this region is crucial for receptor binding and vasoactivity.

The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.

==Disease==

Known disease associated with this structure: High density lipoprotein cholesterol level QTL 7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131240 131240]]

==About this Structure==

1EDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].

1EDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].

==Reference==

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Line 16:

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Janes, R.W.]]

[[Category: Janes, R W.]]

[[Category: Wallace, B.A.]]

[[Category: Wallace, B A.]]

[[Category: signal polypeptide g-protein coupled-receptor ligand]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:42:~~12 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:36 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1edn.gif|left|200px]]<br />
+[[Image:1edn.gif|left|200px]]<br /><applet load="1edn" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1edn" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1edn, resolution 2.18&Aring;" />
 '''HUMAN ENDOTHELIN-1'''<br />
 ==Overview==
-The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by, X-ray crystallography to 2.18 A resolution. This intermediate-sized, structure was solved by molecular replacement techniques using a fragment, of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models, derived from NMR data indicate some important differences, especially in, the carboxy-terminal region of the molecule: the entire carboxy terminal, tail (residues 16-21) is helical in the crystal structure, but not in any, of the NMR structures. This may be a functionally significant difference, as this region is crucial for receptor binding and vasoactivity.
+The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.
+==Disease==
+Known disease associated with this structure: High density lipoprotein cholesterol level QTL 7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131240 131240]]
 ==About this Structure==
-EDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].
+EDN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].
 ==Reference==
@@ Line 14: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Janes, R.W.]]
+[[Category: Janes, R W.]]
-[[Category: Wallace, B.A.]]
+[[Category: Wallace, B A.]]
 [[Category: signal polypeptide g-protein coupled-receptor ligand]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:42:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:36 2008''