1efh: Difference between revisions

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==Overview==

The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has, been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine, 5'-phosphate (PAP). The overall structure is similar to those of SULT1, enzymes such as estrogen sulfotransferase and the PAP binding site is, conserved, however, significant differences exist in the positions of, loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding, pocket. Moreover, protein interaction in the crystal structure has, revealed a possible dimer-directed conformational alteration that may, regulate the SULT activity.

The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine 5'-phosphate (PAP). The overall structure is similar to those of SULT1 enzymes such as estrogen sulfotransferase and the PAP binding site is conserved, however, significant differences exist in the positions of loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding pocket. Moreover, protein interaction in the crystal structure has revealed a possible dimer-directed conformational alteration that may regulate the SULT activity.

==Disease==

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[[Category: Single protein]]

[[Category: Negishi, M.]]

[[Category: Pedersen, L.C.]]

[[Category: Pedersen, L C.]]

[[Category: Petrotchenko, E.V.]]

[[Category: Petrotchenko, E V.]]

[[Category: A3P]]

[[Category: a3p]]

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[[Category: sult2a3]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:27:14 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has, been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine, 5'-phosphate (PAP). The overall structure is similar to those of SULT1, enzymes such as estrogen sulfotransferase and the PAP binding site is, conserved, however, significant differences exist in the positions of, loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding, pocket. Moreover, protein interaction in the crystal structure has, revealed a possible dimer-directed conformational alteration that may, regulate the SULT activity.
+The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine 5'-phosphate (PAP). The overall structure is similar to those of SULT1 enzymes such as estrogen sulfotransferase and the PAP binding site is conserved, however, significant differences exist in the positions of loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding pocket. Moreover, protein interaction in the crystal structure has revealed a possible dimer-directed conformational alteration that may regulate the SULT activity.
 ==Disease==
@@ Line 18: / Line 18: @@
 [[Category: Single protein]]
 [[Category: Negishi, M.]]
-[[Category: Pedersen, L.C.]]
+[[Category: Pedersen, L C.]]
-[[Category: Petrotchenko, E.V.]]
+[[Category: Petrotchenko, E V.]]
 [[Category: A3P]]
 [[Category: a3p]]
@@ Line 28: / Line 28: @@
 [[Category: sult2a3]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:42:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:27:14 2008''