1eh2: Difference between revisions
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==Overview== | ==Overview== | ||
Eps15 homology (EH) domains are eukaryotic signaling modules that | Eps15 homology (EH) domains are eukaryotic signaling modules that recognize proteins containing Asn-Pro-Phe (NPF) sequences. The structure of the central EH domain of Eps15 has been solved by heteronuclear magnetic resonance spectroscopy. The fold consists of a pair of EF hand motifs, the second of which binds tightly to calcium. The NPF peptide is bound in a hydrophobic pocket between two alpha helices, and binding is mediated by a critical aromatic interaction as revealed by structure-based mutagenesis. The fold is predicted to be highly conserved among 30 identified EH domains and provides a structural basis for defining EH-mediated events in protein trafficking and growth factor signaling. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beer, T | [[Category: Beer, T De.]] | ||
[[Category: Carter, R | [[Category: Carter, R E.]] | ||
[[Category: Lobel-Rice, K | [[Category: Lobel-Rice, K E.]] | ||
[[Category: Overduin, M.]] | [[Category: Overduin, M.]] | ||
[[Category: Sorkin, A.]] | [[Category: Sorkin, A.]] | ||
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[[Category: signaling domain]] | [[Category: signaling domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:27:39 2008'' | ||
