3r92: Difference between revisions

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[[Image:3r92.jpg|left|200px]]
[[Image:3r92.png|left|200px]]


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{{STRUCTURE_3r92|  PDB=3r92  |  SCENE=  }}  
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===Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.===
===Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.===


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{{ABSTRACT_PUBMED_21605975}}
{{ABSTRACT_PUBMED_21605975}}


==About this Structure==
==About this Structure==
[[3r92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R92 OCA].  
[[3r92]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R92 OCA].  
 
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]


==Reference==
==Reference==

Revision as of 16:52, 26 July 2012

File:3r92.png

Template:STRUCTURE 3r92

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.

Template:ABSTRACT PUBMED 21605975

About this Structure

3r92 is a 1 chain structure of Heat Shock Proteins with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Zapf CW, Bloom JD, McBean JL, Dushin RG, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Levin JI. Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3627-31. Epub 2011 Apr 28. PMID:21605975 doi:10.1016/j.bmcl.2011.04.102

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