1epw: Difference between revisions
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New page: left|200px<br /><applet load="1epw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1epw, resolution 1.9Å" /> '''CRYSTAL STRUCTURE OF ... |
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[[Image:1epw.gif|left|200px]]<br /><applet load="1epw" size=" | [[Image:1epw.gif|left|200px]]<br /><applet load="1epw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1epw, resolution 1.9Å" /> | caption="1epw, resolution 1.9Å" /> | ||
'''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''<br /> | '''CRYSTAL STRUCTURE OF CLOSTRIDIUM NEUROTOXIN TYPE B'''<br /> | ||
==Overview== | ==Overview== | ||
Clostridium botulinum neurotoxins are among the most potent toxins to | Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development. | ||
==About this Structure== | ==About this Structure== | ||
1EPW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] with ZN and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] Full crystallographic information is available from [http:// | 1EPW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:19 2008'' | ||
