1es0: Difference between revisions

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[[Image:1es0.gif|left|200px]]<br /><applet load="1es0" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1es0.gif|left|200px]]<br /><applet load="1es0" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1es0, resolution 2.60Å" />

'''CRYSTAL STRUCTURE OF THE MURINE CLASS II ALLELE I-A(G7) COMPLEXED WITH THE GLUTAMIC ACID DECARBOXYLASE (GAD65) PEPTIDE 207-220'''<br />

==Overview==

Susceptibility to murine and human insulin-dependent diabetes mellitus, correlates strongly with major histocompatibility complex (MHC) class II, I-A or HLA-DQ alleles that lack an aspartic acid at position beta57. I-Ag7, lacks this aspartate and is the only class II allele expressed by the, nonobese diabetic mouse. The crystal structure of I-Ag7 was determined at, 2.6 angstrom resolution as a complex with a high-affinity peptide from the, autoantigen glutamic acid decarboxylase (GAD) 65. I-Ag7 has a, substantially wider peptide-binding groove around beta57, which accounts, for distinct peptide preferences compared with other MHC class II alleles., Loss of Asp(beta57) leads to an oxyanion hole in I-Ag7 that can be filled, by peptide carboxyl residues or, perhaps, through interaction with the T, cell receptor.

Susceptibility to murine and human insulin-dependent diabetes mellitus correlates strongly with major histocompatibility complex (MHC) class II I-A or HLA-DQ alleles that lack an aspartic acid at position beta57. I-Ag7 lacks this aspartate and is the only class II allele expressed by the nonobese diabetic mouse. The crystal structure of I-Ag7 was determined at 2.6 angstrom resolution as a complex with a high-affinity peptide from the autoantigen glutamic acid decarboxylase (GAD) 65. I-Ag7 has a substantially wider peptide-binding groove around beta57, which accounts for distinct peptide preferences compared with other MHC class II alleles. Loss of Asp(beta57) leads to an oxyanion hole in I-Ag7 that can be filled by peptide carboxyl residues or, perhaps, through interaction with the T cell receptor.

==About this Structure==

1ES0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1ES0 OCA].

1ES0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES0 OCA].

==Reference==

Line 14:

[[Category: Mus musculus]]

[[Category: Protein complex]]

[[Category: Corper, A.L.]]

[[Category: Corper, A L.]]

[[Category: Teyton, L.]]

[[Category: Wilson, I.A.]]

[[Category: Wilson, I A.]]

[[Category: class ii mhc i-a(g7)]]

[[Category: histocompatibility antigen]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 14~~:15:~~37 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:53 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1es0.gif|left|200px]]<br /><applet load="1es0" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1es0.gif|left|200px]]<br /><applet load="1es0" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1es0, resolution 2.60&Aring;" />
 '''CRYSTAL STRUCTURE OF THE MURINE CLASS II ALLELE I-A(G7) COMPLEXED WITH THE GLUTAMIC ACID DECARBOXYLASE (GAD65) PEPTIDE 207-220'''<br />
 ==Overview==
-Susceptibility to murine and human insulin-dependent diabetes mellitus, correlates strongly with major histocompatibility complex (MHC) class II, I-A or HLA-DQ alleles that lack an aspartic acid at position beta57. I-Ag7, lacks this aspartate and is the only class II allele expressed by the, nonobese diabetic mouse. The crystal structure of I-Ag7 was determined at, 2.6 angstrom resolution as a complex with a high-affinity peptide from the, autoantigen glutamic acid decarboxylase (GAD) 65. I-Ag7 has a, substantially wider peptide-binding groove around beta57, which accounts, for distinct peptide preferences compared with other MHC class II alleles., Loss of Asp(beta57) leads to an oxyanion hole in I-Ag7 that can be filled, by peptide carboxyl residues or, perhaps, through interaction with the T, cell receptor.
+Susceptibility to murine and human insulin-dependent diabetes mellitus correlates strongly with major histocompatibility complex (MHC) class II I-A or HLA-DQ alleles that lack an aspartic acid at position beta57. I-Ag7 lacks this aspartate and is the only class II allele expressed by the nonobese diabetic mouse. The crystal structure of I-Ag7 was determined at 2.6 angstrom resolution as a complex with a high-affinity peptide from the autoantigen glutamic acid decarboxylase (GAD) 65. I-Ag7 has a substantially wider peptide-binding groove around beta57, which accounts for distinct peptide preferences compared with other MHC class II alleles. Loss of Asp(beta57) leads to an oxyanion hole in I-Ag7 that can be filled by peptide carboxyl residues or, perhaps, through interaction with the T cell receptor.
 ==About this Structure==
-ES0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ES0 OCA].
+ES0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES0 OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
-[[Category: Corper, A.L.]]
+[[Category: Corper, A L.]]
 [[Category: Teyton, L.]]
-[[Category: Wilson, I.A.]]
+[[Category: Wilson, I A.]]
 [[Category: class ii mhc i-a(g7)]]
 [[Category: histocompatibility antigen]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:15:37 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:53 2008''