2phb: Difference between revisions

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{{Seed}}
[[Image:2phb.png|left|200px]]
[[Image:2phb.png|left|200px]]


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{{STRUCTURE_2phb|  PDB=2phb  |  SCENE=  }}  
{{STRUCTURE_2phb|  PDB=2phb  |  SCENE=  }}  


===An Orally Efficacious Factor Xa Inhibitor===
===An Orally Efficacious Factor Xa Inhibitor===


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{{ABSTRACT_PUBMED_17683371}}
{{ABSTRACT_PUBMED_17683371}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227600 227600]]
[[2phb]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHB OCA].


==About this Structure==
==See Also==
2PHB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PHB OCA].
*[[Factor Xa|Factor Xa]]


==Reference==
==Reference==
<ref group="xtra">PMID:17683371</ref><references group="xtra"/>
<ref group="xtra">PMID:017683371</ref><references group="xtra"/>
[[Category: Coagulation factor Xa]]
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Fxa coagulation factor inhibitor]]
[[Category: Fxa coagulation factor inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:35:57 2009''

Revision as of 18:38, 26 July 2012

File:2phb.png

Template:STRUCTURE 2phb

An Orally Efficacious Factor Xa Inhibitor

Template:ABSTRACT PUBMED 17683371

About this Structure

2phb is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Kohrt JT, Bigge CF, Bryant JW, Casimiro-Garcia A, Chi L, Cody WL, Dahring T, Dudley DA, Filipski KJ, Haarer S, Heemstra R, Janiczek N, Narasimhan L, McClanahan T, Peterson JT, Sahasrabudhe V, Schaum R, Van Huis CA, Welch KM, Zhang E, Leadley RJ, Edmunds JJ. The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarb oxamide (PD 0348292), an orally efficacious factor Xa inhibitor. Chem Biol Drug Des. 2007 Aug;70(2):100-12. PMID:17683371 doi:10.1111/j.1747-0285.2007.00539.x

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