3pi5: Difference between revisions

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[[Image:3pi5.png|left|200px]]
[[Image:3pi5.png|left|200px]]


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{{STRUCTURE_3pi5|  PDB=3pi5  |  SCENE=  }}  
{{STRUCTURE_3pi5|  PDB=3pi5  |  SCENE=  }}  


===Crystal Structure of Human Beta Secretase in Complex with BFG356===
===Crystal Structure of Human Beta Secretase in Complex with BFG356===


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{{ABSTRACT_PUBMED_21388807}}
{{ABSTRACT_PUBMED_21388807}}


==About this Structure==
==About this Structure==
[[3pi5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PI5 OCA].  
[[3pi5]] is a 3 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PI5 OCA].  
 
==See Also==
*[[Beta secretase|Beta secretase]]


==Reference==
==Reference==
<ref group="xtra">PMID:21388807</ref><ref group="xtra">PMID:19195886</ref><ref group="xtra">PMID:19195887</ref><references group="xtra"/>
<ref group="xtra">PMID:021388807</ref><ref group="xtra">PMID:019195886</ref><ref group="xtra">PMID:019195887</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
[[Category: Rondeau, J M.]]
[[Category: Rondeau, J M.]]
[[Category: Aspartic proteinase]]
[[Category: Enzyme inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 18:50, 26 July 2012

File:3pi5.png

Template:STRUCTURE 3pi5

Crystal Structure of Human Beta Secretase in Complex with BFG356

Template:ABSTRACT PUBMED 21388807

About this Structure

3pi5 is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Rueeger H, Rondeau JM, McCarthy C, Mobitz H, Tintelnot-Blomley M, Neumann U, Desrayaud S. Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1942-7. Epub 2011 Feb 15. PMID:21388807 doi:10.1016/j.bmcl.2011.02.038
  2. Machauer R, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Neumann U, Paganetti P. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1361-5. Epub 2009 Jan 19. PMID:19195886 doi:10.1016/j.bmcl.2009.01.036
  3. Machauer R, Laumen K, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Jaton AL, Desrayaud S, Staufenbiel M, Rabe S, Paganetti P, Neumann U. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1366-70. Epub 2009 Jan 22. PMID:19195887 doi:10.1016/j.bmcl.2009.01.055

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