3hk6: Difference between revisions

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[[Image:3hk6.png|left|200px]]
[[Image:3hk6.png|left|200px]]


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{{STRUCTURE_3hk6|  PDB=3hk6  |  SCENE=  }}  
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===Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit)===
===Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit)===


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{{ABSTRACT_PUBMED_19586901}}
{{ABSTRACT_PUBMED_19586901}}


==About this Structure==
==About this Structure==
[[3hk6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK6 OCA].  
[[3hk6]] is a 4 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK6 OCA].  
 
==See Also==
*[[Thrombin|Thrombin]]


==Reference==
==Reference==
<ref group="xtra">PMID:19586901</ref><ref group="xtra">PMID:15252033</ref><references group="xtra"/>
<ref group="xtra">PMID:019586901</ref><ref group="xtra">PMID:015252033</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Acute phase]]
[[Category: Acute phase]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
[[Category: Calcium]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]

Revision as of 19:08, 26 July 2012

File:3hk6.png

Template:STRUCTURE 3hk6

Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit)

Template:ABSTRACT PUBMED 19586901

About this Structure

3hk6 is a 4 chain structure of Thrombin with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403
  2. Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:https://dx.doi.org/10.1074/jbc.M407272200

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