3cv9: Difference between revisions

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[[Image:3cv9.png|left|200px]]
[[Image:3cv9.png|left|200px]]


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{{STRUCTURE_3cv9|  PDB=3cv9  |  SCENE=  }}  
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===Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3===
===Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3===


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{{ABSTRACT_PUBMED_18937506}}


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==See Also==
==See Also==
*[[Cytochrome P450]]
*[[Cytochrome P450|Cytochrome P450]]


==Reference==
==Reference==
<ref group="xtra">PMID:18937506</ref><ref group="xtra">PMID:18314962</ref><references group="xtra"/>
<ref group="xtra">PMID:018937506</ref><ref group="xtra">PMID:018314962</ref><ref group="xtra">PMID:020731719</ref><references group="xtra"/>
[[Category: Streptomyces griseolus]]
[[Category: Streptomyces griseolus]]
[[Category: Unspecific monooxygenase]]
[[Category: Unspecific monooxygenase]]

Revision as of 19:18, 26 July 2012

File:3cv9.png

Template:STRUCTURE 3cv9

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3

Template:ABSTRACT PUBMED 18937506

About this Structure

3cv9 is a 1 chain structure of Cytochrome P450 with sequence from Streptomyces griseolus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hayashi K, Sugimoto H, Shinkyo R, Yamada M, Ikeda S, Ikushiro S, Kamakura M, Shiro Y, Sakaki T. Structure-Based Design of a Highly Active Vitamin D Hydroxylase from Streptomyces griseolus CYP105A1. Biochemistry. 2008 Oct 21. PMID:18937506 doi:10.1021/bi801222d
  2. Sugimoto H, Shinkyo R, Hayashi K, Yoneda S, Yamada M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T. Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3(,). Biochemistry. 2008 Apr 1;47(13):4017-27. Epub 2008 Mar 4. PMID:18314962 doi:https://dx.doi.org/10.1021/bi7023767
  3. Hayashi K, Yasuda K, Sugimoto H, Ikushiro S, Kamakura M, Kittaka A, Horst RL, Chen TC, Ohta M, Shiro Y, Sakaki T. Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis. FEBS J. 2010 Oct;277(19):3999-4009. doi: 10.1111/j.1742-4658.2010.07791.x., Epub 2010 Aug 20. PMID:20731719 doi:10.1111/j.1742-4658.2010.07791.x

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