2p4j: Difference between revisions
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[[Image:2p4j.png|left|200px]] | [[Image:2p4j.png|left|200px]] | ||
{{STRUCTURE_2p4j| PDB=2p4j | SCENE= }} | {{STRUCTURE_2p4j| PDB=2p4j | SCENE= }} | ||
===Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3=== | ===Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3=== | ||
{{ABSTRACT_PUBMED_17432843}} | {{ABSTRACT_PUBMED_17432843}} | ||
==About this Structure== | ==About this Structure== | ||
[[2p4j]] is a 4 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4J OCA]. | |||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:017432843</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
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[[Category: Beta-secretase]] | [[Category: Beta-secretase]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Hydrolase]] | |||
[[Category: Memapsin]] | [[Category: Memapsin]] | ||
[[Category: Structure based drug design]] | [[Category: Structure based drug design]] | ||
Revision as of 19:19, 26 July 2012
Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3
Template:ABSTRACT PUBMED 17432843
About this Structure
2p4j is a 4 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407. Epub 2007 Apr 14. PMID:17432843 doi:10.1021/jm061338s
