2ofv: Difference between revisions

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{{Seed}}
[[Image:2ofv.png|left|200px]]
[[Image:2ofv.png|left|200px]]


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{{STRUCTURE_2ofv|  PDB=2ofv  |  SCENE=  }}  
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===crystal structure of aminoquinazoline 1 bound to Lck===
===crystal structure of aminoquinazoline 1 bound to Lck===


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{{ABSTRACT_PUBMED_16970394}}
{{ABSTRACT_PUBMED_16970394}}


==Disease==
==About this Structure==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
[[2ofv]] is a 2 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFV OCA].


==About this Structure==
==See Also==
2OFV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFV OCA].
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
*[[Tyrosine kinase|Tyrosine kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:16970394</ref><references group="xtra"/>
<ref group="xtra">PMID:016970394</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
Line 32: Line 21:
[[Category: Kinase domain]]
[[Category: Kinase domain]]
[[Category: Lck]]
[[Category: Lck]]
 
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:08:13 2009''

Revision as of 19:21, 26 July 2012

File:2ofv.png

Template:STRUCTURE 2ofv

crystal structure of aminoquinazoline 1 bound to Lck

Template:ABSTRACT PUBMED 16970394

About this Structure

2ofv is a 2 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Buchanan JL, Buckner WH, Cee VJ, Chai L, Deak HL, Epstein LF, Faust T, Gallant P, Geuns-Meyer SD, Gore A, Gu Y, Henkle B, Hodous BL, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, Masse CE, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, White RD, Zhao H, Zhu L, Zhu X. Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2006 Sep 21;49(19):5671-86. PMID:16970394 doi:https://dx.doi.org/10.1021/jm0605482

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