1f16: Difference between revisions
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New page: left|200px<br /> <applet load="1f16" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f16" /> '''SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTE... |
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[[Image:1f16.gif|left|200px]]<br /> | [[Image:1f16.gif|left|200px]]<br /><applet load="1f16" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1f16" size=" | |||
caption="1f16" /> | caption="1f16" /> | ||
'''SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX'''<br /> | '''SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX'''<br /> | ||
==Overview== | ==Overview== | ||
Apoptosis is stimulated by the insertion of Bax from the cytosol into | Apoptosis is stimulated by the insertion of Bax from the cytosol into mitochondrial membranes. The solution structure of Bax, including the putative transmembrane domain at the C terminus, was determined in order to understand the regulation of its subcellular location. Bax consists of 9 alpha helices where the assembly of helices alpha1 through alpha 8 resembles that of the apoptosis inhibitor, Bcl-x(L). The C-terminal alpha 9 helix occupies the hydrophobic pocket proposed previously to mediate heterodimer formation and bioactivity of opposing members of the Bcl-2 family. The Bax structure shows that the orientation of helix alpha 9 provides simultaneous control over its mitochondrial targeting and dimer formation. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1F16 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1F16 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F16 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Suzuki, M.]] | [[Category: Suzuki, M.]] | ||
[[Category: Tjandra, N.]] | [[Category: Tjandra, N.]] | ||
[[Category: Youle, R | [[Category: Youle, R J.]] | ||
[[Category: helical protein]] | [[Category: helical protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:33:41 2008'' | ||
