1f2q: Difference between revisions

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==Overview==

Allergic responses result from the activation of mast cells by the human, high-affinity IgE receptor. IgE-mediated allergic reactions may develop to, a variety of environmental compounds, but the initiation of a response, requires the binding of IgE to its high-affinity receptor. We have solved, the X-ray crystal structure of the antibody-binding domains of the human, IgE receptor at 2.4 A resolution. The structure reveals a highly bent, arrangement of immunoglobulin domains that form an extended convex surface, of interaction with IgE. A prominent loop that confers specificity for IgE, molecules extends from the receptor surface near an unusual arrangement of, four exposed tryptophans. The crystal structure of the IgE receptor, provides a foundation for the development of new therapeutic approaches to, allergy treatment.

Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolution. The structure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surface of interaction with IgE. A prominent loop that confers specificity for IgE molecules extends from the receptor surface near an unusual arrangement of four exposed tryptophans. The crystal structure of the IgE receptor provides a foundation for the development of new therapeutic approaches to allergy treatment.

==About this Structure==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Garman, S.C.]]

[[Category: Garman, S C.]]

[[Category: Jardetzky, T.S.]]

[[Category: Jardetzky, T S.]]

[[Category: Kinet, J.P.]]

[[Category: Kinet, J P.]]

[[Category: NAG]]

[[Category: glycoprotein]]

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[[Category: receptor]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:12 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Allergic responses result from the activation of mast cells by the human, high-affinity IgE receptor. IgE-mediated allergic reactions may develop to, a variety of environmental compounds, but the initiation of a response, requires the binding of IgE to its high-affinity receptor. We have solved, the X-ray crystal structure of the antibody-binding domains of the human, IgE receptor at 2.4 A resolution. The structure reveals a highly bent, arrangement of immunoglobulin domains that form an extended convex surface, of interaction with IgE. A prominent loop that confers specificity for IgE, molecules extends from the receptor surface near an unusual arrangement of, four exposed tryptophans. The crystal structure of the IgE receptor, provides a foundation for the development of new therapeutic approaches to, allergy treatment.
+Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolution. The structure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surface of interaction with IgE. A prominent loop that confers specificity for IgE molecules extends from the receptor surface near an unusual arrangement of four exposed tryptophans. The crystal structure of the IgE receptor provides a foundation for the development of new therapeutic approaches to allergy treatment.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Garman, S.C.]]
+[[Category: Garman, S C.]]
-[[Category: Jardetzky, T.S.]]
+[[Category: Jardetzky, T S.]]
-[[Category: Kinet, J.P.]]
+[[Category: Kinet, J P.]]
 [[Category: NAG]]
 [[Category: glycoprotein]]
@@ Line 22: / Line 22: @@
 [[Category: receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:45:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:12 2008''