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==Overview==

Clostridium botulinum neurotoxins are among the most potent toxins to, humans. The crystal structures of intact C. botulinum neurotoxin type B, (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A, resolution, respectively, provide insight into its catalytic and binding, sites. The position of the belt region in BoNT/B is different from that in, BoNT/A; this observation presents interesting possibilities for designing, specific inhibitors that could be used to block the activity of this, neurotoxin. The structures of BoNT/B and its complex with sialyllactose, provide a detailed description of the active site and a model for, interactions between the toxin and its cell surface receptor. The latter, may provide valuable information for recombinant vaccine development.

Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development.

==About this Structure==

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[[Category: zinc]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Clostridium botulinum neurotoxins are among the most potent toxins to, humans. The crystal structures of intact C. botulinum neurotoxin type B, (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A, resolution, respectively, provide insight into its catalytic and binding, sites. The position of the belt region in BoNT/B is different from that in, BoNT/A; this observation presents interesting possibilities for designing, specific inhibitors that could be used to block the activity of this, neurotoxin. The structures of BoNT/B and its complex with sialyllactose, provide a detailed description of the active site and a model for, interactions between the toxin and its cell surface receptor. The latter, may provide valuable information for recombinant vaccine development.
+Clostridium botulinum neurotoxins are among the most potent toxins to humans. The crystal structures of intact C. botulinum neurotoxin type B (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A resolution, respectively, provide insight into its catalytic and binding sites. The position of the belt region in BoNT/B is different from that in BoNT/A; this observation presents interesting possibilities for designing specific inhibitors that could be used to block the activity of this neurotoxin. The structures of BoNT/B and its complex with sialyllactose provide a detailed description of the active site and a model for interactions between the toxin and its cell surface receptor. The latter may provide valuable information for recombinant vaccine development.
 ==About this Structure==
@@ Line 26: / Line 26: @@
 [[Category: zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:39:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:17 2008''