1f62: Difference between revisions

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==Overview==

The PHD (plant homeo domain) is a approximately 50-residue motif found, mainly in proteins involved in eukaryotic transcription regulation. The, characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc, binding motif. We have determined the solution structure of the PHD motif, from the human Williams-Beuren syndrome transcription factor (WSTF), protein. The domain folds into an interleaved zinc finger which binds two, Zn(2+) in a similar manner to that of the RING and FYVE domains. The, structure reveals a conserved zinc-binding core, together with two, variable loops that are likely candidates for interactions between the, various PHD domains and their specific ligands.

The PHD (plant homeo domain) is a approximately 50-residue motif found mainly in proteins involved in eukaryotic transcription regulation. The characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc binding motif. We have determined the solution structure of the PHD motif from the human Williams-Beuren syndrome transcription factor (WSTF) protein. The domain folds into an interleaved zinc finger which binds two Zn(2+) in a similar manner to that of the RING and FYVE domains. The structure reveals a conserved zinc-binding core, together with two variable loops that are likely candidates for interactions between the various PHD domains and their specific ligands.

==About this Structure==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Dyson, H.J.]]

[[Category: Dyson, H J.]]

[[Category: Martinez-Yamout, M.]]

[[Category: Pascual, J.]]

[[Category: Wright, P.E.]]

[[Category: Wright, P E.]]

[[Category: ZN]]

[[Category: zn-finger]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The PHD (plant homeo domain) is a approximately 50-residue motif found, mainly in proteins involved in eukaryotic transcription regulation. The, characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc, binding motif. We have determined the solution structure of the PHD motif, from the human Williams-Beuren syndrome transcription factor (WSTF), protein. The domain folds into an interleaved zinc finger which binds two, Zn(2+) in a similar manner to that of the RING and FYVE domains. The, structure reveals a conserved zinc-binding core, together with two, variable loops that are likely candidates for interactions between the, various PHD domains and their specific ligands.
+The PHD (plant homeo domain) is a approximately 50-residue motif found mainly in proteins involved in eukaryotic transcription regulation. The characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc binding motif. We have determined the solution structure of the PHD motif from the human Williams-Beuren syndrome transcription factor (WSTF) protein. The domain folds into an interleaved zinc finger which binds two Zn(2+) in a similar manner to that of the RING and FYVE domains. The structure reveals a conserved zinc-binding core, together with two variable loops that are likely candidates for interactions between the various PHD domains and their specific ligands.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Dyson, H.J.]]
+[[Category: Dyson, H J.]]
 [[Category: Martinez-Yamout, M.]]
 [[Category: Pascual, J.]]
-[[Category: Wright, P.E.]]
+[[Category: Wright, P E.]]
 [[Category: ZN]]
 [[Category: zn-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:46:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:35:15 2008''