3c09: Difference between revisions

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[[Image:3c09.png|left|200px]]
[[Image:3c09.png|left|200px]]


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{{STRUCTURE_3c09|  PDB=3c09  |  SCENE=  }}  
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===Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR===
===Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR===


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{{ABSTRACT_PUBMED_18394559}}
{{ABSTRACT_PUBMED_18394559}}


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==See Also==
==See Also==
*[[Epidermal Growth Factor Receptor]]
*[[Epidermal Growth Factor Receptor|Epidermal Growth Factor Receptor]]
*[[Monoclonal Antibody]]
*[[Monoclonal Antibody|Monoclonal Antibody]]


==Reference==
==Reference==
<ref group="xtra">PMID:18394559</ref><references group="xtra"/>
<ref group="xtra">PMID:018394559</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens, mus musculus]]
[[Category: Homo sapiens, mus musculus]]
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[[Category: Antitumor]]
[[Category: Antitumor]]
[[Category: Cell surface receptor]]
[[Category: Cell surface receptor]]
[[Category: Drug immune system/transferase complex]]
[[Category: Drug immune system-transferase complex]]
[[Category: Fab fragment]]
[[Category: Fab fragment]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Immune system-transferase complex]]

Revision as of 22:34, 26 July 2012

File:3c09.png

Template:STRUCTURE 3c09

Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR

Template:ABSTRACT PUBMED 18394559

About this Structure

3c09 is a 6 chain structure of Epidermal Growth Factor Receptor and Monoclonal Antibody with sequence from Homo sapiens and Homo sapiens, mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Schmiedel J, Blaukat A, Li S, Knochel T, Ferguson KM. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008 Apr;13(4):365-73. PMID:18394559 doi:10.1016/j.ccr.2008.02.019

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