3m36: Difference between revisions

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[[Image:3m36.png|left|200px]]
[[Image:3m36.png|left|200px]]


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{{STRUCTURE_3m36|  PDB=3m36  |  SCENE=  }}  
{{STRUCTURE_3m36|  PDB=3m36  |  SCENE=  }}  


===Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)===
===Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)===


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{{ABSTRACT_PUBMED_14640539}}
{{ABSTRACT_PUBMED_14640539}}


==About this Structure==
==About this Structure==
[[3m36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M36 OCA].  
[[3m36]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M36 OCA].  
 
==See Also==
*[[Factor Xa|Factor Xa]]


==Reference==
==Reference==
<ref group="xtra">PMID:14640539</ref><references group="xtra"/>
<ref group="xtra">PMID:014640539</ref><references group="xtra"/>
[[Category: Coagulation factor Xa]]
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Plasma]]
[[Category: Plasma]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Protein inhibitor complex]]
[[Category: Protein inhibitor complex]]

Revision as of 23:06, 26 July 2012

File:3m36.png

Template:STRUCTURE 3m36

Factor XA in complex with the inhibitor 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423)

Template:ABSTRACT PUBMED 14640539

About this Structure

3m36 is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR. Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1). J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539 doi:10.1021/jm030212h

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