3kn0: Difference between revisions
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[[Image:3kn0.png|left|200px]] | [[Image:3kn0.png|left|200px]] | ||
{{STRUCTURE_3kn0| PDB=3kn0 | SCENE= }} | {{STRUCTURE_3kn0| PDB=3kn0 | SCENE= }} | ||
===Structure of BACE bound to SCH708236=== | ===Structure of BACE bound to SCH708236=== | ||
{{ABSTRACT_PUBMED_20043700}} | {{ABSTRACT_PUBMED_20043700}} | ||
==About this Structure== | ==About this Structure== | ||
[[3kn0]] is a 2 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KN0 OCA]. | |||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020043700</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Strickland, C.]] | [[Category: Strickland, C.]] | ||
[[Category: Wang, Y.]] | [[Category: Wang, Y.]] | ||
[[Category: Alzheimers']] | [[Category: Alzheimers']] | ||
[[Category: Aspartyl protease]] | [[Category: Aspartyl protease]] | ||
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[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 23:40, 26 July 2012
Structure of BACE bound to SCH708236
Template:ABSTRACT PUBMED 20043700
About this Structure
3kn0 is a 2 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wang YS, Strickland C, Voigt JH, Kennedy ME, Beyer BM, Senior MM, Smith EM, Nechuta TL, Madison VS, Czarniecki M, McKittrick BA, Stamford AW, Parker EM, Hunter JC, Greenlee WJ, Wyss DF. Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J Med Chem. 2009 Dec 31. PMID:20043700 doi:10.1021/jm901472u
