3lox: Difference between revisions

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[[Image:3lox.jpg|left|200px]]
[[Image:3lox.png|left|200px]]


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{{STRUCTURE_3lox|  PDB=3lox  |  SCENE=  }}  
{{STRUCTURE_3lox|  PDB=3lox  |  SCENE=  }}  


===HCV NS3-4a protease domain with a ketoamide inhibitor derivative of Boceprevir bound===
===HCV NS3-4a protease domain with a ketoamide inhibitor derivative of Boceprevir bound===


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{{ABSTRACT_PUBMED_20303756}}
{{ABSTRACT_PUBMED_20303756}}


==About this Structure==
==About this Structure==
[[3lox]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOX OCA].  
[[3lox]] is a 4 chain structure of [[Proliferating Cell Nuclear Antigen]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOX OCA].  
 
==See Also==
*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]]


==Reference==
==Reference==
<ref group="xtra">PMID:20303756</ref><references group="xtra"/>
<ref group="xtra">PMID:020303756</ref><references group="xtra"/>
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Prongay, A J.]]
[[Category: Prongay, A J.]]
[[Category: Atp-binding]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Ketoamide inhibitor]]
[[Category: Membrane]]
[[Category: Ns3 protease domain]]
[[Category: Nucleotide-binding]]
[[Category: Rna replication]]
[[Category: Serine protease]]
[[Category: Transmembrane]]

Revision as of 00:13, 27 July 2012

File:3lox.png

Template:STRUCTURE 3lox

HCV NS3-4a protease domain with a ketoamide inhibitor derivative of Boceprevir bound

Template:ABSTRACT PUBMED 20303756

About this Structure

3lox is a 4 chain structure of Proliferating Cell Nuclear Antigen with sequence from Hepatitis c virus subtype 1a. Full crystallographic information is available from OCA.

See Also

Reference

  1. Bennett F, Huang Y, Hendrata S, Lovey R, Bogen SL, Pan W, Guo Z, Prongay A, Chen KX, Arasappan A, Venkatraman S, Velazquez F, Nair L, Sannigrahi M, Tong X, Pichardo J, Cheng KC, Girijavallabhan VM, Saksena AK, Njoroge FG. The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2617-21. Epub 2010 Feb 19. PMID:20303756 doi:10.1016/j.bmcl.2010.02.063

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