3h1v: Difference between revisions

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{{Seed}}
[[Image:3h1v.png|left|200px]]
[[Image:3h1v.jpg|left|200px]]


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{{STRUCTURE_3h1v|  PDB=3h1v  |  SCENE=  }}  
{{STRUCTURE_3h1v|  PDB=3h1v  |  SCENE=  }}  


===Human glucokinase in complex with a synthetic activator===
===Human glucokinase in complex with a synthetic activator===


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{{ABSTRACT_PUBMED_19736020}}
{{ABSTRACT_PUBMED_19736020}}


==Disease==
==About this Structure==
Known disease associated with this structure: Diabetes mellitus, gestational OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], Diabetes mellitus, noninsulin-dependent, late onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], Diabetes mellitus, permanent neonatal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], Hyperinsulinemic hypoglycemia, familial, 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], MODY, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]]
[[3h1v]] is a 1 chain structure of [[Hexokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1V OCA].  


==About this Structure==
==See Also==
3H1V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1V OCA].
*[[Hexokinase|Hexokinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:19736020</ref><references group="xtra"/>
<ref group="xtra">PMID:019736020</ref><references group="xtra"/>
[[Category: Glucokinase]]
[[Category: Glucokinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Takahashi, K.]]
[[Category: Takahashi, K.]]
[[Category: Allosteric activator]]
[[Category: Allosteric activator]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Diabetes]]
[[Category: Diabetes]]
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Polymorphism]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  7 14:04:44 2009''

Revision as of 00:26, 27 July 2012

File:3h1v.png

Template:STRUCTURE 3h1v

Human glucokinase in complex with a synthetic activator

Template:ABSTRACT PUBMED 19736020

About this Structure

3h1v is a 1 chain structure of Hexokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Takahashi K, Hashimoto N, Nakama C, Kamata K, Sasaki K, Yoshimoto R, Ohyama S, Hosaka H, Maruki H, Nagata Y, Eiki J, Nishimura T. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem. 2009 Oct 1;17(19):7042-51. Epub 2009 May 21. PMID:19736020 doi:10.1016/j.bmc.2009.05.037

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