4dru: Difference between revisions

Revision as of 01:26, 27 July 2012

4dru is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Cummings MD, Lin TI, Hu L, Tahri A, McGowan D, Amssoms K, Last S, Devogelaere B, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, Van Emelen K, Nyanguile O, Simmen K, Raboisson P, Vendeville S. Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties. Angew Chem Int Ed Engl. 2012 Mar 30. doi: 10.1002/anie.201200110. PMID:22473861 doi:10.1002/anie.201200110

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-[[Image:4dru.jpg|left|200px]]
+[[Image:4dru.png|left|200px]]
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 {{STRUCTURE_4dru|  PDB=4dru  |  SCENE=  }}
 ===HCV NS5B in complex with macrocyclic INDOLE INHIBITOR===
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 {{ABSTRACT_PUBMED_22473861}}
 ==About this Structure==
-[[4dru]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRU OCA].
+[[4dru]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRU OCA].
+==See Also==
+*[[RNA polymerase|RNA polymerase]]
 ==Reference==