2puq: Difference between revisions

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{{Seed}}
[[Image:2puq.png|left|200px]]
[[Image:2puq.png|left|200px]]


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{{STRUCTURE_2puq|  PDB=2puq  |  SCENE=  }}  
{{STRUCTURE_2puq|  PDB=2puq  |  SCENE=  }}  


===Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor===
===Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor===


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{{ABSTRACT_PUBMED_17456045}}
{{ABSTRACT_PUBMED_17456045}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Renal tubular dysgenesis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=106180 106180]], Angiotensin I-converting enzyme, benign serum increase OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=106180 106180]], Alzheimer disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=106180 106180]], Microvascular complications of diabetes 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=106180 106180]], Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=106180 106180]], SARS, progression of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=106180 106180]]
[[2puq]] is a 4 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pmm 2pmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUQ OCA].  


==About this Structure==
==See Also==
2PUQ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pmm 2pmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PUQ OCA].
*[[Factor VIIa|Factor VIIa]]


==Reference==
==Reference==
<ref group="xtra">PMID:17456045</ref><references group="xtra"/>
<ref group="xtra">PMID:017456045</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 33: Line 21:
[[Category: Active site inhibitor]]
[[Category: Active site inhibitor]]
[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Substrate profile]]
[[Category: Hydrolase]]
 
[[Category: Hydrolase-hydrolase inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:56:17 2009''

Revision as of 01:46, 27 July 2012

File:2puq.png

Template:STRUCTURE 2puq

Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor

Template:ABSTRACT PUBMED 17456045

About this Structure

2puq is a 4 chain structure of Factor VIIa with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2pmm. Full crystallographic information is available from OCA.

See Also

Reference

  1. Larsen KS, Ostergaard H, Bjelke JR, Olsen OH, Rasmussen HB, Christensen L, Kragelund BB, Stennicke HR. Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa. Biochem J. 2007 Aug 1;405(3):429-38. PMID:17456045 doi:https://dx.doi.org/10.1042/BJ20061901

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