3d20: Difference between revisions

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[[Image:3d20.png|left|200px]]
[[Image:3d20.png|left|200px]]


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{{STRUCTURE_3d20|  PDB=3d20  |  SCENE=  }}  
{{STRUCTURE_3d20|  PDB=3d20  |  SCENE=  }}  


===Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA===
===Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA===


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{{ABSTRACT_PUBMED_18597780}}
{{ABSTRACT_PUBMED_18597780}}


==About this Structure==
==About this Structure==
[[3d20]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D20 OCA].  
[[3d20]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D20 OCA].  
 
==See Also==
*[[Virus protease|Virus protease]]


==Reference==
==Reference==
<ref group="xtra">PMID:18597780</ref><ref group="xtra">PMID:16962136</ref><ref group="xtra">PMID:16277992</ref><references group="xtra"/>
<ref group="xtra">PMID:018597780</ref><ref group="xtra">PMID:016962136</ref><ref group="xtra">PMID:016277992</ref><references group="xtra"/>
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Capsid maturation]]
[[Category: Capsid maturation]]
[[Category: Capsid protein]]
[[Category: Capsid protein]]
[[Category: Cytoplasm]]
[[Category: Dna integration]]
[[Category: Dna integration]]
[[Category: Dna recombination]]
[[Category: Dna recombination]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Ribosomal frameshifting]]
[[Category: Rna-binding]]
[[Category: Rna-binding]]
[[Category: Rna-directed dna polymerase]]
[[Category: Rna-directed dna polymerase]]
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[[Category: Viral nucleoprotein]]
[[Category: Viral nucleoprotein]]
[[Category: Virion]]
[[Category: Virion]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Revision as of 01:57, 27 July 2012

File:3d20.png

Template:STRUCTURE 3d20

Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA

Template:ABSTRACT PUBMED 18597780

About this Structure

3d20 is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

See Also

Reference

  1. Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:18597780 doi:10.1016/j.jmb.2008.05.062
  2. Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007
  3. Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095

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