1t4v: Difference between revisions

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{{Seed}}
[[Image:1t4v.png|left|200px]]
[[Image:1t4v.png|left|200px]]


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{{STRUCTURE_1t4v|  PDB=1t4v  |  SCENE=  }}  
{{STRUCTURE_1t4v|  PDB=1t4v  |  SCENE=  }}  


===Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin===
===Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin===


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{{ABSTRACT_PUBMED_15203151}}
{{ABSTRACT_PUBMED_15203151}}


==Disease==
==About this Structure==
Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]]
[[1t4v]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4V OCA].


==About this Structure==
==See Also==
1T4V is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4V OCA].
*[[Hirudin|Hirudin]]
*[[Thrombin|Thrombin]]


==Reference==
==Reference==
<ref group="xtra">PMID:15203151</ref><references group="xtra"/>
<ref group="xtra">PMID:015203151</ref><references group="xtra"/>
[[Category: Hirudo medicinalis]]
[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Spurlino, J.]]
[[Category: Spurlino, J.]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:36:48 2009''

Revision as of 01:59, 27 July 2012

File:1t4v.png

Template:STRUCTURE 1t4v

Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin

Template:ABSTRACT PUBMED 15203151

About this Structure

1t4v is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. PMID:15203151 doi:https://dx.doi.org/10.1016/j.bmcl.2004.05.002

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