1zpc: Difference between revisions

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{{Seed}}
[[Image:1zpc.png|left|200px]]
[[Image:1zpc.png|left|200px]]


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===Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide===
===Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide===


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{{ABSTRACT_PUBMED_16524727}}
{{ABSTRACT_PUBMED_16524727}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]], Factor XI deficiency, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]]
[[1zpc]] is a 1 chain structure of [[Factor XIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPC OCA].


==About this Structure==
==See Also==
1ZPC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPC OCA].
*[[Factor XIa|Factor XIa]]


==Reference==
==Reference==
<ref group="xtra">PMID:16524727</ref><references group="xtra"/>
<ref group="xtra">PMID:016524727</ref><references group="xtra"/>
[[Category: Coagulation factor XIa]]
[[Category: Coagulation factor XIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Strickler, J E.]]
[[Category: Strickler, J E.]]
[[Category: Fxi]]
[[Category: Fxi]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:52:32 2009''

Revision as of 02:20, 27 July 2012

File:1zpc.png

Template:STRUCTURE 1zpc

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide

Template:ABSTRACT PUBMED 16524727

About this Structure

1zpc is a 1 chain structure of Factor XIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:16524727 doi:https://dx.doi.org/10.1016/j.bmcl.2006.02.052

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