2fbv: Difference between revisions

Revision as of 02:23, 27 July 2012

Ligands:

MN

Gene:

WRN, RECQ3, RECQL2 (Homo sapiens)

Related:

2fbt, 2fbx, 2fby, 2fc0

Structural annotation:
Resources:	InterPro : Ipr004589, Ipr014021, Ipr014001, Ipr002464, Ipr001650, Ipr002121, Ipr002562, Ipr012337, Ipr011545 Pfam : PF01612 UniProt : Q14191

Functional annotation:
Cellular component:	nucleus intracellular
Biological process:	regulation of growth rate aging DNA recombination telomere maintenance
Molecular function:	3'-5' exonuclease activity hydrolase activity DNA binding helicase activity nucleotide binding ATP binding DNA helicase activity nucleic acid binding protein binding ATP-dependent helicase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2fbv is a 1 chain structure of Helicase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA. WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol. 2006 May;13(5):414-22. Epub 2006 Apr 23. PMID:16622405 doi:https://dx.doi.org/10.1038/nsmb1088

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