2bin: Difference between revisions

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[[Image:2bin.png|left|200px]]
[[Image:2bin.png|left|200px]]


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{{STRUCTURE_2bin|  PDB=2bin  |  SCENE=  }}  
{{STRUCTURE_2bin|  PDB=2bin  |  SCENE=  }}  


===HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-N268D===
===HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-N268D===


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{{ABSTRACT_PUBMED_15703170}}
{{ABSTRACT_PUBMED_15703170}}


==About this Structure==
==About this Structure==
[[2bin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIN OCA].  
[[2bin]] is a 1 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIN OCA].  
 
==See Also==
*[[P53|P53]]


==Reference==
==Reference==
<ref group="xtra">PMID:15703170</ref><ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:8023157</ref><references group="xtra"/>
<ref group="xtra">PMID:015703170</ref><ref group="xtra">PMID:014534297</ref><ref group="xtra">PMID:008023157</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fersht, A R.]]
[[Category: Fersht, A R.]]
[[Category: Joerger, A C.]]
[[Category: Joerger, A C.]]
[[Category: 3d-structure]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Anti-oncogene]]
[[Category: Anti-oncogene]]
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[[Category: P53 dna-binding domain]]
[[Category: P53 dna-binding domain]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Second-site suppressor mutation]]
[[Category: Second-site suppressor mutation]]
[[Category: Superstable mutant]]
[[Category: Superstable mutant]]

Revision as of 03:09, 27 July 2012

File:2bin.png

Template:STRUCTURE 2bin

HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-N268D

Template:ABSTRACT PUBMED 15703170

About this Structure

2bin is a 1 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:https://dx.doi.org/10.1074/jbc.M500179200
  2. Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
  3. Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157

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