2db3: Difference between revisions

Revision as of 03:47, 27 July 2012

Ligands:

ANP, MG

Gene:

VASA (Drosophila melanogaster)

Activity:

Adenosinetriphosphatase, with EC number 3.6.1.3

Structural annotation:
Resources:	InterPro : Ipr014014, Ipr014021, Ipr014001, Ipr011545, Ipr000629, Ipr001650 Pfam : PF00271, PF00270 UniProt : P09052

Functional annotation:
Cellular component:	polar granule
Biological process:	germarium-derived oocyte fate determination germarium-derived egg chamber formation pole plasm RNA localization positive regulation of oskar mRNA translation cell differentiation positive regulation of translation intracellular mRNA localization dorsal appendage formation multicellular organismal development karyosome formation oocyte anterior/posterior axis determination oogenesis pole plasm assembly germ-line cyst formation regulation of oskar mRNA translation mRNA polyadenylation
Molecular function:	helicase activity nucleotide binding protein binding ATP-dependent helicase activity RNA binding nucleic acid binding RNA helicase activity ATP binding hydrolase activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, PDBsum, RCSB, TOPSAN

Coordinates:

save as pdb, mmCIF, xml

2db3 is a 8 chain structure of Helicase with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Sengoku T, Nureki O, Nakamura A, Kobayashi S, Yokoyama S. Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell. 2006 Apr 21;125(2):287-300. PMID:16630817 doi:10.1016/j.cell.2006.01.054
Sengoku T, Nureki O, Dohmae N, Nakamura A, Yokoyama S. Crystallization and preliminary X-ray analysis of the helicase domains of Vasa complexed with RNA and an ATP analogue. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):320-2. Epub 2004, Jan 23. PMID:14747711 doi:10.1107/S0907444903025897

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 ==See Also==
 *[[Helicase|Helicase]]
-*[[User:Wayne Decatur|User:Wayne Decatur]]
 ==Reference==