1g3j: Difference between revisions

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[[Image:1g3j.gif|left|200px]]<br />

[[Image:1g3j.gif|left|200px]]<br /><applet load="1g3j" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1g3j" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1g3j, resolution 2.1Å" />

'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''<br />

==Overview==

The Wnt signaling pathway plays critical roles in embryonic development, and tumorigenesis. Stimulation of the Wnt pathway results in the, accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target, genes. A crystal structure of beta-catenin bound to the beta-catenin, binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms, an elongated structure with three binding modules that runs antiparallel, to beta-catenin along the positively charged groove formed by the, armadillo repeats. Structure-based mutagenesis defines three sites in, beta-catenin that are critical for binding the Tcf3-CBD and are, differentially involved in binding APC, cadherin, and Axin. The structural, and mutagenesis data reveal a potential target for molecular drug design, studies.

The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.

==Disease==

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==About this Structure==

1G3J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1G3J OCA].

1G3J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3J OCA].

==Reference==

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[[Category: Protein complex]]

[[Category: Xenopus laevis]]

[[Category: Graham, T.A.]]

[[Category: Graham, T A.]]

[[Category: Kimelman, D.]]

[[Category: Mao, F.]]

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[[Category: tcf-3]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 17:00:~~11 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:45:38 2008''

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-[[Image:1g3j.gif|left|200px]]<br />
+[[Image:1g3j.gif|left|200px]]<br /><applet load="1g3j" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1g3j" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1g3j, resolution 2.1&Aring;" />
 '''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''<br />
 ==Overview==
-The Wnt signaling pathway plays critical roles in embryonic development, and tumorigenesis. Stimulation of the Wnt pathway results in the, accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target, genes. A crystal structure of beta-catenin bound to the beta-catenin, binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms, an elongated structure with three binding modules that runs antiparallel, to beta-catenin along the positively charged groove formed by the, armadillo repeats. Structure-based mutagenesis defines three sites in, beta-catenin that are critical for binding the Tcf3-CBD and are, differentially involved in binding APC, cadherin, and Axin. The structural, and mutagenesis data reveal a potential target for molecular drug design, studies.
+The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-G3J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1G3J OCA].
+G3J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3J OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Protein complex]]
 [[Category: Xenopus laevis]]
-[[Category: Graham, T.A.]]
+[[Category: Graham, T A.]]
 [[Category: Kimelman, D.]]
 [[Category: Mao, F.]]
@@ Line 27: / Line 26: @@
 [[Category: tcf-3]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:00:11 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:45:38 2008''